1610693-40-7Relevant academic research and scientific papers
Vitamin B1 supported on alumina as an efficient heterogeneous catalyst for synthesis of tetrahydro-2,6-dioxopyrimidin-4-yl)-2,3-dihydrophthalazine-1,4-dione derivatives
Biabangard, Asiyeh,Shaterian, Hamid Reza
, p. 1529 - 1534 (2015)
The efficient synthesis of tetrahydro-2,6-dioxopyrimidin-4-yl)-2,3-dihydrophthalazine-1,4-dione derivatives via four-component reaction of hydrazine hydrate, phthalic anhydride, aromatic aldehydes and barbituric acid using vitamin B1 supported on alumina (VB1-Al2O3) as a heterogeneous catalyst under thermal solvent-free conditions in excellent yields is described.
FeCl3-catalyzed three-component reaction: A novel synthesis of tetrahydro-2,6-dioxopyrimidin-4-yl-2,3-dihydrophthalazine-1,4-dione derivatives under solvent-free conditions
Reddy Mudumala, Veeranarayana,Rani Chinthaparthi, Radha,Jeong Yeon, Tae
, p. 3762 - 3769 (2014/05/20)
Three-component coupling of phthalhydrazide, aldehydes, and barbituric acid has been accomplished in the presence of 15 mol % FeCl3 under solvent-free conditions to afford the corresponding tetrahydro-2,6- dioxopyrimidin-4-yl)-2,3-dihydrophthalazine-1,4-dione derivatives in excellent yields. This method provides high yields, shorter reaction time, and mild reaction conditions. This is the first example of the condensation of phthalhydrazide, aldehydes, and barbituric acid to provide a novel series of phthalhydrazide derivatives.
