1610767-27-5

Basic information

• Product Name: C₂₀H₂₁N₃O₃S
• CAS NO: 1610767-27-5
• Molecular Weight: 383.471
• Mol File: 1610767-27-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₁N₃O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₁N₃O₃S(1610767-27-5)
• EPA Substance Registry System: C₂₀H₂₁N₃O₃S(1610767-27-5)

Safety Data

• Hazardous Substances Data: 1610767-27-5(Hazardous Substances Data)

Upstream product

• 10039-64-2 ethyl 3-(3-aminophenyl)propanoate 

Downstream Products

• 1610767-34-4 C₂₁H₂₃N₃O₃S 
• 1610767-42-4 C₂₂H₂₃N₅O₃ 
• 1610767-44-6 C₁₉H₁₇N₅O₃ 

Relevant articles and documents

Design, synthesis and biological evaluation of novel inosine 5′-monophosphate dehydrogenase (IMPDH) inhibitors

This study is based on our attempts to further explore the structure-activity relationship (SAR) of VX-148 (3) in an attempt to identify inosine 5′-mono-phosphate dehydrogenase (IMPDH) inhibitors superior to mycophenolic acid. A five-point pharmacophore developed using structurally diverse, known IMPDH inhibitors guided further design of novel analogs of 3. Several conventional as well as novel medicinal chemistry strategies were tried. The combined structure- and ligand-based approaches culminated in a few analogs with either retained or slightly higher potency. The compounds which retained the potency were also checked for their ability to inhibit human peripheral blood mononuclear cells proliferation. This study illuminates the stringent structural requirements and strict SAR for IMPDH II inhibition.