1610774-89-4

Basic information

• Product Name: C₂₆H₃₉N₃O₆
• Synonyms: C₂₆H₃₉N₃O₆
• CAS NO: 1610774-89-4
• Molecular Weight: 489.612
• Mol File: 1610774-89-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₆H₃₉N₃O₆(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₆H₃₉N₃O₆(1610774-89-4)
• EPA Substance Registry System: C₂₆H₃₉N₃O₆(1610774-89-4)

Safety Data

• Hazardous Substances Data: 1610774-89-4(Hazardous Substances Data)

Upstream product

• 1610774-91-8 C₂₇H₃₆N₂O₆ 
• 1620672-86-7 C₁₇H₂₄N₂O₅ 
• 247068-84-4 (2S)-2-amino-4-methyl-1-[(2R)-2-methyloxiran-2-yl]pentan-1-one 
• 247068-82-2 tert-butyl ((2S)-4-methyl-1-((2R)-2-methyloxirane-2-yl)-1-oxopentan-2-yl)carbamate 
• 1620672-78-7 C₂₂H₂₈N₂O₄ 

Relevant articles and documents

Development of a new class of proteasome inhibitors with an epoxyketone warhead: Rational hybridization of non-peptidic belactosin derivatives and peptide epoxyketones

Proteasome inhibitors are currently a focus of increased attention as anticancer drug candidates. We recently performed systematic structure-activity relationship studies of the peptidic natural product belactosin A and identified non-peptidic derivative 2 as a highly potent proteasome inhibitor. However, the cell growth inhibitory effect of 2 is only moderate, probably due to the biologically unstable β-lactone warhead. Peptide epoxyketones are an important class of proteasome inhibitors exhibit high potency in cellular systems based on the efficient α,β-epoxyketone warhead. Importantly, belactosin derivatives bind primarily to the primed binding site, while peptide epoxyketones bind only to the non-primed binding site of proteasome, suggesting that hybridization of them might lead to the development of a new class of proteasome inhibitors. Thus, we successfully identified a novel chemotype of proteasome inhibitors 3 and 4 by rational structure-based design, which are expected to bind to both the primed and non-primed binding sites of proteasome.