1610784-97-8

Basic information

• Product Name: N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-bromophenoxy)acetamide
• Synonyms: N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-bromophenoxy)acetamide
• CAS NO: 1610784-97-8
• Molecular Weight: 351.203
• Mol File: 1610784-97-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-bromophenoxy)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-bromophenoxy)acetamide(1610784-97-8)
• EPA Substance Registry System: N-((4-amino-2-methylpyrimidin-5-yl)methyl)-2-(2-bromophenoxy)acetamide(1610784-97-8)

Safety Data

• Hazardous Substances Data: 1610784-97-8(Hazardous Substances Data)

Upstream product

• 95-56-7 2-hydroxybromobenzene 
• 95-02-3 5-(aminomethyl)-2-methylpyrimidin-4-amine 
• 1879-56-7 2-(2-bromophenoxy)acetic acid 
• 63423-50-7 5‐(azidomethyl)‐2‐methylpyrimidin‐4‐amine 

Relevant articles and documents

Design, synthesis and molecular docking of amide and urea derivatives as Escherichia coli PDHc-E1 inhibitors

By targeting the ThDP binding site of Escherichia coli PDHc-E1, two new 'open-chain' classes of E. coli PDHc-E1 inhibitors, amide and urea derivatives, were designed, synthesized, and evaluated. The amide derivatives of compound 6d, with 4-NO2 in the benzene ring, showed the most potent inhibition of E. coli PDHc-E1. The urea derivatives displayed more potent inhibitory activity than the corresponding amide derivatives with the same substituent. Molecular docking studies confirmed that the urea derivatives have more potency due to the two hydrogen bonds formed by two NH of urea with Glu522. The docking results also indicate it might help us to design more efficient PDHc-E1 inhibitors that could interact with Glu522.