1610833-32-3Relevant academic research and scientific papers
Enantioselective rhodium-catalyzed C-C bond activation of cyclobutanones
Souillart, Laetitia,Cramer, Nicolai
, p. 187 - 190 (2015)
The activation of carbon-carbon bonds has attracted much attention in the past decade. Despite important progress, the development of asymmetric reactions lags behind. For the first time, asymmetric rhodium(i)-catalyzed direct oxidative additions into ena
Highly enantioselective rhodium(I)-catalyzed activation of enantiotopic cyclobutanone C-C bonds
Souillart, Laetitia,Parker, Evelyne,Cramer, Nicolai
supporting information, p. 3001 - 3005 (2014/04/03)
The selective functionalization of carbon-carbon σ bonds is a synthetic strategy that offers uncommon retrosynthetic disconnections. Despite progress in C-C activation and its great importance, the development of asymmetric reactions lags behind. Rhodium(I)-catalyzed selective oxidative additions into enantiotopic C-C bonds in cyclobutanones are reported. Even operating at a reaction temperature of 130 °C, the process is characterized by outstanding enantioselectivity with the e.r. generally greater than 99.5:0.5. The intermediate rhodacycle is shown to react with a wide variety of tethered olefins to deliver complex bicyclic ketones in high yields.
