1610885-82-9Relevant academic research and scientific papers
Palladium-catalyzed decarboxylative C3-acylation of benzofurans and benzothiophenes with α-oxocarboxylic acids via direct sp2 C-H bond activation
Gong, Wei-Jie,Liu, De-Xian,Li, Fei-Long,Gao, Jun,Li, Hong-Xi,Lang, Jian-Ping
, p. 1269 - 1275 (2015/03/03)
An efficient approach to decarboxylative C3-acylation of benzothiophenes or benzofurans with α-oxocarboxylic acids via palladium-catalyzed C-H bond activation was developed. This method was compatible with a variety of functional groups and provided an attractive route to 3-acylbenzothiophenes and 3-acylbenzofurans in good to high yields.
Regioselective ruthenium-catalyzed carbonylative direct arylation of five-membered and condensed heterocycles
Pospech, Jola,Tlili, Anis,Spannenberg, Anke,Neumann, Helfried,Beller, Matthias
, p. 3135 - 3141 (2014/03/21)
A ruthenium-catalyzed carbonylative Ci￡H bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed. By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp2)i￡C(sp2) bond formation has been achieved. This straightforward catalytic process provides access to versatile products prevalent in multiple bioactive compounds and supplies a valuable functional group for subsequent transformations. Ci￡ H bond functionalization: A ruthenium-catalyzed carbonylative Ci￡H bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed (see scheme). By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp2) i￡C(sp2) bond formation has been achieved.
