1610885-95-4Relevant academic research and scientific papers
Palladium-catalyzed direct C2-and further C7-acylation of indoles with aldehydes
Zhang, Hui-Jun,Wu, Zhengjian,Lin, Weidong,Wen, Ting-Bin
, p. 517 - 521 (2015)
The palladium-catalyzed direct C2- and further C7-acylation of indoles with aldehydes have been developed. This method provides a convenient pathway toward a variety of mono- and diacylated indoles. The palladium-catalyzed direct C2- and further C7-acylat
Merger of Visible-Light Photoredox Catalysis and C-H Activation for the Room-Temperature C-2 Acylation of Indoles in Batch and Flow
Sharma, Upendra K.,Gemoets, Hannes P. L.,Schr?der, Felix,No?l, Timothy,Van Der Eycken, Erik V.
, p. 3818 - 3823 (2017/06/19)
A mild and versatile protocol for the C-H acylation of indoles via dual photoredox/transition-metal catalysis was established in batch and flow. The C-H bond functionalization occurred selectively at the C-2 position of N-pyrimidylindoles. This room-temperature protocol tolerated a wide range of functional groups and allowed for the synthesis of a diverse set of acylated indoles. Various aromatic as well as aliphatic aldehydes (both primary and secondary) reacted successfully. Interestingly, significant acceleration (20 to 2 h) and higher yields were obtained under micro flow conditions.
Regioselective ruthenium-catalyzed carbonylative direct arylation of five-membered and condensed heterocycles
Pospech, Jola,Tlili, Anis,Spannenberg, Anke,Neumann, Helfried,Beller, Matthias
supporting information, p. 3135 - 3141 (2014/03/21)
A ruthenium-catalyzed carbonylative Ci￡H bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed. By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp2)i￡C(sp2) bond formation has been achieved. This straightforward catalytic process provides access to versatile products prevalent in multiple bioactive compounds and supplies a valuable functional group for subsequent transformations. Ci￡ H bond functionalization: A ruthenium-catalyzed carbonylative Ci￡H bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed (see scheme). By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp2) i￡C(sp2) bond formation has been achieved.
