1610886-26-4Relevant articles and documents
Regioselective ruthenium-catalyzed carbonylative direct arylation of five-membered and condensed heterocycles
Pospech, Jola,Tlili, Anis,Spannenberg, Anke,Neumann, Helfried,Beller, Matthias
, p. 3135 - 3141 (2014/03/21)
A ruthenium-catalyzed carbonylative Ci£H bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed. By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp2)i£C(sp2) bond formation has been achieved. This straightforward catalytic process provides access to versatile products prevalent in multiple bioactive compounds and supplies a valuable functional group for subsequent transformations. Ci£ H bond functionalization: A ruthenium-catalyzed carbonylative Ci£H bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed (see scheme). By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp2) i£C(sp2) bond formation has been achieved.