1610930-09-0

Basic information

• Product Name: 1-(4-(2-(2-(4-trifluoromethylphenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea
• Synonyms: 1-(4-(2-(2-(4-trifluoromethylphenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea
• CAS NO: 1610930-09-0
• Molecular Weight: 651.952
• Mol File: 1610930-09-0.mol

Chemical Properties

• CAS DataBase Reference: 1-(4-(2-(2-(4-trifluoromethylphenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-(2-(2-(4-trifluoromethylphenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea(1610930-09-0)
• EPA Substance Registry System: 1-(4-(2-(2-(4-trifluoromethylphenylacetyl)hydrazinocarbonyl)pyridine-4-yloxy)phenyl)-3-(4-chloro-3-trifluoromethylphenyl)urea(1610930-09-0)

Safety Data

• Hazardous Substances Data: 1610930-09-0(Hazardous Substances Data)

Upstream product

• 24484-93-3 4-Chloro-pyridine-2-carboxylic acid methyl ester 
• 123-30-8 4-amino-phenol 
• 757251-59-5 methyl 4‐(4‐aminophenoxy)picolinate 
• 32857-62-8 4-Trifluoromethylphenylacetic acid 

Relevant articles and documents

Synthesis and in vitro cytotoxic activities of sorafenib derivatives

A series of novel sorafenib derivatives have been designed and synthesized. The cytotoxic activities of these compounds were tested in three tumor cell lines. Most of the compounds showed potent antiproliferative activity against the tested cell lines with IC50 = 0-20 μmol/L. Some compounds demonstrated competitive antiproliferative activities to sorafenib against all three cancer cell lines. Among them, compound 5g demonstrated significant inhibitory activity against A549, ACHN and MDA-MB-231 cell lines with IC 50 values of 1.29, 1.99, 3.11 μmol/L, respectively.