1610948-84-9

Upstream product

• 277317-84-7 (2R/S,3R)-3-(Benzyloxy)tetrahydro-4,4-dimethylfuran-2-ol 
• 1610948-82-7 (S)-3-(benzyloxy)-2,2-dimethylhex-4-enal 
• 1610948-83-8 ((((S)-1-methoxy-3,3-dimethylhepta-1,5-dien-4-yl)oxy)methyl)benzene 
• 1610948-81-6 (S)-3-(benzyloxy)-2,2-dimethylhex-4-en-1-ol 

Downstream Products

• 1610948-85-0 (S)-(((5,5-dimethyloct-2-en-7-yn-4-yl)oxy)methyl)benzene 
• 1610948-86-1 dimethyl (R)-3-(benzyloxy)-2,2,6-trimethyl-2,3-dihydro-1H-indene-4, 5-dicarboxylate 
• 1610948-87-2 (R)-8-(benzyloxy)-4,7,7-trimethyl-7,8-dihydrocyclopenta[e]isoindole-1,3(2H,6H)-dione 

Relevant academic research and scientific papers

NOVEL TRICYCLIC COMPOUNDS AND PREPARATION THEREOF

The present invention provides novel tricyclic compound of Formula I or its stereoisomer or ester or pharmaceutically acceptable salts and preparation thereof useful for treatment of cancer.

NOVEL TRICYCLIC COMPOUNDS AND PREPARATION THEREOF

The present invention provides a novel tricyclic compound of Formula I or its stereoisomer or ester or pharmaceutically acceptable salts and preparation thereof useful for in treatment of cancer.

Total synthesis of an anticancer norsesquiterpene alkaloid isolated from the fungus Flammulina velutipes

The first total synthesis of a norsesquiterpene alkaloid (R)-8-hydroxy-4,7,7-trimethyl-7,8-dihydrocyclopenta[e]isoindole-1,3(2H,6H) -dione, isolated from the mushroom-forming fungus Flammulina velutipes, in both racemic and enantiomeric pure forms, is reported. The (-)-enantiomer of the natural product has been synthesized from the d-(-)-pantolactone chiral pool. The synthesis features a one-pot, three-step reaction sequence comprising an enyne RCM/Diels-Alder/aromatization to construct the desired indane skeleton present in the natural product. Our synthesis further confirms the assigned structure and absolute configuration of the natural product. This journal is the Partner Organisations 2014.