161097-77-4

Basic information

• Product Name: CIMICIFUGOSIDE H-2
• Synonyms: CIMICIFUGOSIDE H-2;CIMICIFUGOSIDE H-2(AS)
• CAS NO: 161097-77-4
• Molecular Formula: C₃₅H₅₄O₁₀
• Molecular Weight: 634.8
• Product Categories: Miscellaneous Natural Products
• Mol File: 161097-77-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 801.0±65.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3 (20 ºC 760 Torr)
• PKA: 12.80±0.20(Predicted)
• CAS DataBase Reference: CIMICIFUGOSIDE H-2(CAS DataBase Reference)
• NIST Chemistry Reference: CIMICIFUGOSIDE H-2(161097-77-4)
• EPA Substance Registry System: CIMICIFUGOSIDE H-2(161097-77-4)

Safety Data

• Hazardous Substances Data: 161097-77-4(Hazardous Substances Data)

Usage

General Description

Cimicifugoside H-2 is a chemical compound found in the plant Cimicifuga foetida, commonly known as Shengma. It belongs to the triterpene glycoside family and has been studied for its potential pharmacological activities, including its anti-inflammatory and anti-tumor effects. Cimicifugoside H-2 has also been reported to have estrogenic and anti-estrogenic activities, making it a subject of interest for research in women's health and hormone-related conditions. The compound has shown promise in various pre-clinical studies, and further research is ongoing to explore its potential therapeutic applications.

Relevant articles and documents

Studies on the Chinese crude drug 'shoma'. IX. Three novel cycloanostanol xylosides, cimicifugosides H-1, H-2 and H-5, from Cimicifuga Rhizome

Three new cyclolanostanol xylosides were isolated from a batch of commercial Cimicifuga Rhizome, cimicifugoside H-1 (1), C35H52O9, mp 260-262°C, [α](D) -43.5°, cimicifugoside H-2 (2), C35H54O10, mp 227-229°C, [α](D) -38.8°, and cimicifugoside H-5 (3), C35H52O10, mp 262-264°C, [α](D) -22.9°, together with known glycosides, actein and 27-deoxyactein. Their structures were determined on the basis of chemical and spectrometric evidence including an X-ray crystallographic analysis. The structure of cimicifugoside H-1 (1) was established as (20R,24R)-24,25-epoxy-11β-hydroxy-3-β-(β-D-xylopyranosyloxy)-9,19-c yclolanost-7-ene-16,23-dione. Cimicifugoside H-5 (3) is the 15-hydroxylated derivative of 1. Since 1 changed into cimicifugoside H-2 (2) on treatment with p-toluenesulfonic acid, 2 has a 24R,25-diol structure derived from 1 by opening its epoxy ring.