16111-99-2

Upstream product

• 874-23-7 2-acetylcyclohexanone 
• 107-21-1 ethylene glycol 

Downstream Products

• 26343-65-7 threo-2-(1-Hydroxyethyl)cyclohexanone 
• 152837-05-3 (Z)-2-<1-(Trimethylsilyl)ethylidene>cyclohexan-1-ol 
• 152836-91-4 (Z)-2-<1-(Trimethylsilyl)ethylidene>cyclohexanone 
• 159419-06-4 2-(1-tert-Butyl-1-hydroxyethyl)cyclohexanone 

Relevant academic research and scientific papers

Synthesis of 2-(1,4-dioxaspiro[4.5]decan-6-yl)acrylamides from 2-acetylcyclohexanone via palladium-catalysed aminocarbonylation

6-(1-Iodovinyl)-1,4-dioxaspiro[4.5]decane, an iodoalkene obtained from 2-acetylcyclohexanone via ethylene ketal formation, hydrazone formation and iodination, was aminocarbonylated in the presence of a palladium-phosphine precatalyst. Systematic investigations revealed that 2-(1,4-dioxaspiro[4.5]decan-6-yl)acrylamides can be obtained in high yields via palladium-catalysed aminocarbonylation. The influence of the amine nucleophiles and of the reaction conditions on the isolated yields was investigated. Graphical abstract: (Chemical Equation Presented).