161117-67-5

Basic information

• Product Name: 2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONAMIDE
• Synonyms: 2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONAMIDE
• CAS NO: 161117-67-5
• Molecular Formula: C₁₄H₂₁NO₃S
• Molecular Weight: 283.39
• Mol File: 161117-67-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 159-161 °C
• Boiling Point: 450.3°C at 760 mmHg
• Flash Point: 226.1°C
• Appearance: /
• Density: 1.163g/cm³
• Vapor Pressure: 2.67E-08mmHg at 25°C
• Refractive Index: 1.535
• PKA: 10.63±0.40(Predicted)
• CAS DataBase Reference: 2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONAMIDE(161117-67-5)
• EPA Substance Registry System: 2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONAMIDE(161117-67-5)

Safety Data

• Hazardous Substances Data: 161117-67-5(Hazardous Substances Data)

Usage

General Description

2,2,5,7,8-Pentamethylchroman-6-sulfonamide is a chemical compound with potential antioxidant and anti-inflammatory properties. It is a derivative of Vitamin E and has been studied for its ability to protect cells from oxidative stress and reduce inflammation. 2,2,5,7,8-PENTAMETHYLCHROMAN-6-SULFONAMIDE has shown promise in the treatment of various diseases and conditions associated with oxidative damage and inflammation, including cardiovascular disease, neurodegenerative disorders, and skin aging. Its unique structure and properties make it a potential candidate for the development of therapeutic agents for a range of health issues.

InChI:InChI=1/C14H21NO3S/c1-8-9(2)13(19(15,16)17)10(3)11-6-7-14(4,5)18-12(8)11/h6-7H2,1-5H3,(H2,15,16,17)

Upstream product

• 55646-01-0 2,2,5,7,8-pentamethyl-chromane 
• 112160-39-1 2,2,5,7,8-pentamethylchroman-6-sulfonyl chloride 

Downstream Products

• 947748-49-4 N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(2,6-dichlorophenyl)thiourea 
• 947748-71-2 N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-N''-bis(p-nitrophenyl)guanidine 
• 947748-67-6 C₅₇H₆₆N₆O₈S₂ 
• 947748-66-5 N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-allyl-N''-(o-methoxyphenyl)guanidine 
• 947748-61-0 N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-cyclohexyl-N''-benzyloxyguanidine 
• 947748-57-4 N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(p-nitrophenyl)thiourea 
• 947748-55-2 N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-(o-methoxyphenyl)thiourea 
• 773147-13-0 N-2,2,5,7,8-pentamethylchroman-6-sulfonyl-N'-benzylthiourea 

Relevant articles and documents

Strategies for the solid-phase diversification of poly-L-proline-type II peptide mimic scaffolds and peptide scaffolds through guanidinylation

(Chemical Equation Presented) A strategy for the solid-phase diversification of PPII mimic scaffolds through guanidinylation is presented. The approach involves the synthesis N-Pmc-N′-alkyl thioureas as diversification reagents. Analogues of Fmoc-Orn(Mtt)-OH can be incorporated into a growing peptide chain on Wang resin. Side chain deprotection with 1% TFA/CH2Cl2 followed by EDCI-mediated reaction of N-Pmc-N′-alkyl thioureas with the side chain amine affords arginine analogues with modified guanidine head groups. The scope, limitations, and incidental chemistry are discussed.

Enantioselective total synthesis of (-)-dehydrobatzelladine C

The oxidation of two tethered Biginelli adducts was examined as a potential key step in total syntheses of highly oxidized batzelladine and crambescidin alkaloids. Although angular hydroxyl substitution could not be introduced, dehydrogenation was readily accomplished. This latter conversion is a key step in the first total synthesis of dehydrobatzelladine C.