161117-83-5

Basic information

• Product Name: tert-butyl 2-methoxypyridin-3-ylcarbamate
• Synonyms: tert-butyl 2-methoxypyridin-3-ylcarbamate;3-(N-tert-butoxycarbonylaMino)-2-Methoxypyridine;CarbaMic acid, (2-Methoxy-3-pyridinyl)-, 1,1-diMethylethyl ester
• CAS NO: 161117-83-5
• Molecular Formula: C₁₁H₁₆N₂O₃
• Molecular Weight: 224.26
• Mol File: 161117-83-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 276.0±25.0 °C(Predicted)
• Appearance: /
• Density: 1.146±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 12.31±0.70(Predicted)
• CAS DataBase Reference: tert-butyl 2-methoxypyridin-3-ylcarbamate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 2-methoxypyridin-3-ylcarbamate(161117-83-5)
• EPA Substance Registry System: tert-butyl 2-methoxypyridin-3-ylcarbamate(161117-83-5)

Safety Data

• Hazardous Substances Data: 161117-83-5(Hazardous Substances Data)

Usage

General Description

Tert-butyl 2-methoxypyridin-3-ylcarbamate is a chemical compound with the molecular formula C13H20N2O3. It falls under the category of carbamates, a group of organic compounds that are derived from carbamic acid. Its structure consists of a pyridinyl group, a tert-butyl functional group, a carbamate group, and a methoxy group. As it is specialized and complex chemical, it likely to be used in research and development, potentially as a precursor in the synthesis of other chemical compounds or in specific chemical reactions. The exact properties such as boiling point, melting point, density, and specific rotations may vary based on the purity and other factors. Always use caution and proper safety procedures when working with this compound as with other types of chemicals.

InChI:InChI=1S/C11H16N2O3/c1-11(2,3)16-10(14)13-8-6-5-7-12-9(8)15-4/h5-7H,1-4H3,(H,13,14)

Upstream product

• 20265-38-7 3-amino-2-methoxypyridine 
• 24608-52-4 tert-butyl chloroformate 
• 24424-99-5 di-tert-butyl dicarbonate 

Downstream Products

• 162709-22-0 4-Formyl-2-methoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester 
• 175965-74-9 4-fluoro-2-methoxypyridin-3-amine 
• 1338219-67-2 2,3-dihydro-1H-pyrrolo[2,3-c]pyridin-7-yl(phenyl)methanone 
• 1338219-65-0 7-chloro-2,3-dihydro-1H-pyrrolo[2,3-c]pyridine 
• 684-16-2 Hexafluoroacetone 
• 162709-20-8 4-Iodo-2-methoxy-3-pyridinecarbamic acid 1,1-dimethylethyl ester 
• 162709-18-4 2-Methoxy-4-(phenylmethyl)-3-pyridinecarbamic acid 1,1-dimethylethyl ester 

Relevant articles and documents

Synthesis method of 8-chloro-1, 7-naphthyridine-3-formaldehyde

The invention discloses a synthesis method of 8-chloro-1, 7-naphthyridine-3-formaldehyde, which comprises the following synthesis steps: 1) taking a compound I 2-methoxy-3-aminopyridine as an initialraw material, protecting amino to obtain a compound II; 2) reacting the compound II with an hydroformylation reagent under an alkaline condition to obtain a compound III; 3) deprotecting the compoundIII under an acidic condition to obtain a compound IV or a salt of the compound IV; 4) performing cyclization reaction on the compound IV and an acrylate compound under the action of a Lewis acid to prepare a compound V; 5) carrying out chlorination reaction on the compound V and a chlorination reagent to prepare a compound VI; and 6) dissolving the compound VI 8-chloro-1, 7-naphthyridine-3-formate as a raw material in a solvent, and reducing under the action of a reducing reagent to directly obtain 8-chloro-1, 7-naphthyridine-3-formaldehyde, namely a compound VII. The preparation method disclosed by the invention has the characteristics of suitability for industrial production, relatively low cost and simple operation.

Preparation of azaindolines and benzoyl substituted azaindolines: Precursors of triazabenzo[cd]azulen-9-one PDE4 inhibitors

The syntheses of various substituted azaindolines are described. Azaindolines were identified as potential key intermediates towards new PDE4 inhibitors.

QUINAZOLINE DERIVATIVE

This invention provides a compound or its pharmaceutically-acceptable salt of formula (I) wherein R 1 represents a lower alkyl group et al; R 2 and R 3 are same and different and represents hydrogen atm et al; R 4 represents the substituent of the formula (II) et al; X 1 represents NH, O or S; Y represents N or C; Ar is a divalent substituent derived from aryl et al, by removing two hydrogen atoms therefrom; the ring A represents a 5- or 6-membered heteroaryl group; this compounds has a histamine-H3 receptor antagonistic effect or a histamine-H3 receptor inverse-agonistic effect and is useful for preventive or remedy of metabolic system diseases, circulatory system diseases or nervous system diseases.