161121-02-4

Basic information

• Product Name: (S)-1-(3,4-DIMETHOXYPHENYL)-2-PROPANOL
• Synonyms: (S)-1-(3,4-DIMETHOXYPHENYL)-2-PROPANOL;(S)-1-(3,4-DIMETHOXYPHENYL)-PROPAN-2-OL;(2S)-1-(3,4-diMethoxyphenyl)propan-2-ol;2-Propanol, l-(3,4-dimethoxyphenyl)-;MFCD01697000
• CAS NO: 161121-02-4
• Molecular Formula: C₁₁H₁₆O₃
• Molecular Weight: 196.24
• Mol File: 161121-02-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 296.556 °C at 760 mmHg
• Flash Point: 133.153 °C
• Appearance: /
• Density: 1.063 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.511
• Storage Temp.: 2-8°C
• PKA: 14.86±0.20(Predicted)
• CAS DataBase Reference: (S)-1-(3,4-DIMETHOXYPHENYL)-2-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(3,4-DIMETHOXYPHENYL)-2-PROPANOL(161121-02-4)
• EPA Substance Registry System: (S)-1-(3,4-DIMETHOXYPHENYL)-2-PROPANOL(161121-02-4)

Safety Data

• Hazardous Substances Data: 161121-02-4(Hazardous Substances Data)

Usage

General Description

(S)-1-(3,4-Dimethoxyphenyl)-2-propanol is a chemical compound with the molecular formula C11H16O3. It is a chiral secondary alcohol that is commonly used as a building block in organic synthesis. The compound has two methoxy groups and a phenyl group attached to the carbon atom, giving it a unique structure. It can be produced through a variety of synthetic methods, and is often used as a precursor in the production of pharmaceuticals and other fine chemicals. Its chiral nature makes it a valuable tool for creating enantiomerically pure compounds, which are important in the pharmaceutical industry. The compound may also have other potential applications in the fields of materials science and organic chemistry.

InChI:InChI=1/C11H16O3/c1-8(12)6-9-4-5-10(13-2)11(7-9)14-3/h4-5,7-8,12H,6H2,1-3H3/t8-/m0/s1

Upstream product

• 165821-73-8 Toluene-4-sulfonic acid (R)-3-(3,4-dimethoxy-phenyl)-2-hydroxy-propyl ester 
• 776-99-8 3,4-dimethoxyphenylacetone 
• 6379-72-2 1,2-dimethoxy-4-(E)-propenylbenzene 

Relevant articles and documents

Wickerhamomyces subpelliculosus as whole-cell biocatalyst for stereoselective bioreduction of ketones

Newly isolated strains of Wickerhamomyces subpelliculosus were recognized as excellent whole-cell biocatalyst for bioreduction of various ketones. The biocatalytic properties of the new strains were demonstrated in this study by stereoselective bioreduction of acetophenone 1a, 2-heptanone 1b, phenylacetone 1c, 3,4-dimethoxyphenylacetone 1d and 1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanone 1e. Our study is the first report on application of W. subpelliculosus as whole-cell biocatalyst for stereoselective bioreduction of prochiral ketones. In these processes, both the freshly harvested cell paste and the lyophilized cell powder were tested as biocatalyst using glucose or 2-propanol at various concentrations as cosubstrates for cofactor regeneration. The newly isolated strains of W. subpelliculosus showed diverse characteristics, including optimal pH, temperature and organic solvent tolerance. Bioreductions of phenylacetone 1c applying glucose as cosubstrate under various mild conditions resulted (S)-1-phenylpropanol [(S)-2c] in good to excellent conversion (c = 63.4%–99.9%) with excellent enantiomeric excess [ee(S)-2c = 98.7%–99.8%].

Organocatalytic approach to (s)-1-arylpropan-2-ols: Enantioselective synthesis of the key intermediate of antiepileptic agent (-)-talampanel

An efficient organocatalytic route for the preparation of enantioselective synthesis of (S)-1-arylpropan-2-ols derivatives, including the key intermediate of antiepileptic agent (-)-talampanel is described. The key steps involved are L-proline-catalyzed a

Stereoselective production of (S)-1-aralkyl- and 1-arylethanols by freshly harvested and lyophilized yeast cells

Substituted (S)-1-phenyl- 2a-h and (S)-1-benzyl-propan-2-ols 4a and b, and (S)-1-phenylethanol 6 were produced from prochiral ketones 1a-h, 3a,b and 5 by reductions with freshly harvested Zygosaccharomyces rouxii and Debaryomyces hansenii cells. The bioreductions were also performed by lyophilized cells. Comparison of the secondary alcohols from the bioreductions 2b-e,g,h and 4a and authentic (S)-alcohols (S)-2b-e,g,h and (S)-4a synthesized from enantiopure (S)-methyloxirane 7 proved the absolute configuration of the products.