161121-03-5

Basic information

• Product Name: (R)-1-(3, 4-DIMETHOXYPHENYL)-2-PROPANOL
• Synonyms: (R)-1-(3, 4-DIMETHOXYPHENYL)-2-PROPANOL;(R)-1-(3,4-DiMethoxy-phenyl)-propan-2-ol
• CAS NO: 161121-03-5
• Molecular Formula: C11H16O3
• Molecular Weight: 196.24
• Mol File: 161121-03-5.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 296.556 °C at 760 mmHg
• Flash Point: 133.153 °C
• Appearance: /
• Density: 1.063g/cm³
• Storage Temp.: 2-8°C
• PKA: 14.86±0.20(Predicted)
• CAS DataBase Reference: (R)-1-(3, 4-DIMETHOXYPHENYL)-2-PROPANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-1-(3, 4-DIMETHOXYPHENYL)-2-PROPANOL(161121-03-5)
• EPA Substance Registry System: (R)-1-(3, 4-DIMETHOXYPHENYL)-2-PROPANOL(161121-03-5)

Safety Data

• Hazardous Substances Data: 161121-03-5(Hazardous Substances Data)

Usage

General Description

(R)-1-(3,4-Dimethoxyphenyl)-2-propanol is a chiral compound with a molecular formula of C11H16O3. It is also known by the name "pinoresinol." This chemical is a natural lignan found in plant sources such as sesame seeds and other medicinal plants. Pinoresinol has been studied for its potential health benefits, including its antioxidant and anti-inflammatory properties. It has also been investigated for its potential as a natural remedy for various health conditions, such as cardiovascular diseases and cancer. Additionally, pinoresinol is used in the food and pharmaceutical industries as a natural additive due to its potential health-promoting properties.

Upstream product

• 776-99-8 3,4-dimethoxyphenylacetone 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 165821-73-8 Toluene-4-sulfonic acid (R)-3-(3,4-dimethoxy-phenyl)-2-hydroxy-propyl ester 
• 6379-72-2 1,2-dimethoxy-4-(E)-propenylbenzene 
• 37629-53-1 (E)-1,2-dimethoxy-4-(2-nitroprop-1-enyl)benzene 
• 91-16-7 1,2-dimethoxybenzene 
• 187737-37-7 propene 
• 93-15-2 1,2-dimethoxy-4-(2-propenyl)benzene 

Downstream Products

• 115247-49-9 (4,5-dimethoxy-2-nitro-phenyl)-acetone 
• 6379-72-2 1,2-dimethoxy-4-(E)-propenylbenzene 
• 1604039-14-6 4-(2-iodopropyl)-1,2-dimethoxybenzene 
• 1604040-03-0 2-((9-(3,4-dimethoxyphenyl)-8-methylnon-6-yn-1-yl)oxy)tetrahydro-2H-pyran 
• 1604039-79-3 4-(4-(3,4-dimethoxyphenyl)-3-methylbut-1-yn-1-yl)-N,N-dimethylaniline 
• 1450816-79-1 (E)-ethyl 3-(4,5-dimethoxy-2-(2-methoxypropyl)phenyl)acrylate 
• 57230-44-1 Naphthalen-1-yl-carbamic acid 3,4-dimethoxy-benzyl ester 

Relevant articles and documents

Free Radical Scavenging Activity of Essential Oil of Eugenia caryophylata from Amboina Island and Derivatives of Eugenol

Essential oil from Eugenia caryophylata was normally used to heal many different deseaces. Various chemical compositions of essential oil distilled and steamed of Moluccas Eugenia caryophylata has been investigated by many different researchers. Even though an intensive research has been carried out of the local chemotypes, a very detail study has not been fully investigated to find out the complete chemical compounds from the plant essential oil and its content associated with their biological activities. In present paper, we assess the free radical scavenging of E. caryophylata collected from Moluccas islands, Indonesia. Essential oil was extracted from leaves, buds, and stems of plant by steam distillation and analyzed using GC-FID and GC-MS. The result showed that free radical activity of essential oil, main constituent and its derivatives were analized using in vitro method. Essential oil activity from stem obtained as (0.82±0.15 μg/mL) was higher than that from bud and leaf possessing both 1,1-diphenyl-2-picrylhydrazyl (DPPH) and (2,2'-azino-bis-3-ethylbenzthizoline-6-sulphonic acid (ABTS) radical scavenging assays by sinergism of eugenol, eugenyl acetate, β-caryophylene and humulene. The activity of isoeugenol (2) (3.59±0.54 μM) and (5.0±0.53 μM) scavenging DPPH and ABTS, respectively, as derivatives eugenol was higher than (3), (4) and (5). Although (6) was active originally, it was inactive after conversion of the ester. While the change of the double bond of location to conjungation structure caused more activity scavenging radicals than the starting molecule.

BICYCLO 2,3-BENZODIAZEPINES AND SPIROCYCLICALLY SUBSTITUTED 2,3-BENZODIAZEPINES

BET-protein-inhibitory, in particular BRD4-inhibitory bicyclo- and spirocyclically substituted 2,3-benzodiazepines of the general formula (I), pharmaceutical compositions comprising the compounds according to the invention, and the prophylactic and therap

Wickerhamomyces subpelliculosus as whole-cell biocatalyst for stereoselective bioreduction of ketones

Newly isolated strains of Wickerhamomyces subpelliculosus were recognized as excellent whole-cell biocatalyst for bioreduction of various ketones. The biocatalytic properties of the new strains were demonstrated in this study by stereoselective bioreduction of acetophenone 1a, 2-heptanone 1b, phenylacetone 1c, 3,4-dimethoxyphenylacetone 1d and 1-cyclopropyl-2-(2-methoxy-4-nitrophenoxy)ethanone 1e. Our study is the first report on application of W. subpelliculosus as whole-cell biocatalyst for stereoselective bioreduction of prochiral ketones. In these processes, both the freshly harvested cell paste and the lyophilized cell powder were tested as biocatalyst using glucose or 2-propanol at various concentrations as cosubstrates for cofactor regeneration. The newly isolated strains of W. subpelliculosus showed diverse characteristics, including optimal pH, temperature and organic solvent tolerance. Bioreductions of phenylacetone 1c applying glucose as cosubstrate under various mild conditions resulted (S)-1-phenylpropanol [(S)-2c] in good to excellent conversion (c = 63.4%–99.9%) with excellent enantiomeric excess [ee(S)-2c = 98.7%–99.8%].