1611469-27-2Relevant academic research and scientific papers
Trifluoroethanethiol: An additive for efficient one-pot peptide ligation - Desulfurization chemistry
Thompson, Robert E.,Liu, Xuyu,Alonso-García, Noelia,Pereira, Pedro José Barbosa,Jolliffe, Katrina A.,Payne, Richard J.
, p. 8161 - 8164 (2014/06/24)
Native chemical ligation followed by desulfurization is a powerful strategy for the assembly of proteins. Here we describe the development of a high-yielding, one-pot ligation-desulfurization protocol that uses trifluoroethanethiol (TFET) as a novel thiol additive. The synthetic utility of this TFET-enabled methodology is demonstrated by the efficient multi-step one-pot syntheses of two tick-derived proteins, chimadanin and madanin-1, without the need for any intermediary purification.
