1611470-76-8

Basic information

• Product Name: C₂₀H₂₂N₂O₂
• Synonyms: C₂₀H₂₂N₂O₂
• CAS NO: 1611470-76-8
• Molecular Weight: 322.407
• Mol File: 1611470-76-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₀H₂₂N₂O₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₀H₂₂N₂O₂(1611470-76-8)
• EPA Substance Registry System: C₂₀H₂₂N₂O₂(1611470-76-8)

Safety Data

• Hazardous Substances Data: 1611470-76-8(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 95-20-5 2-methyl-1H-indole 
• 127704-26-1 2-(dimorpholinomethyl)phenol 

Downstream Products

• 1611470-95-1 4-(9-(1-benzyl-2-methyl-1H-indol-3-yl)-2,3,4,4a,9,9a-hexahydro-1H-xanthen-4a-yl)morpholine 

Relevant articles and documents

The hit-to-lead optimization of 1,2,3,4,4a,9a-hexahydro-1H-xanthenes as glucocorticoid receptor antagonists

The structure-activity relationship (SAR) study of a 1,2,3,4,4a,9a- hexahydro-1H-xanthene series of selective, human glucocorticoid receptor α (hGRα) antagonists is reported. Compounds were screened using hydroxyapatite-based GR binding and MMTV-Luc co-transfection reporter gene assays. Four different regions of the scaffold were modified to assess the effects on hGRα antagonism and related potency. Compound 8d exhibits an 8-fold better bioactivity than the original hit 1a, as well as an improved chemical stability, which make it a promising lead for the subsequent optimization.