1611478-34-2Relevant academic research and scientific papers
Enantioselective addition of silicon nucleophiles to aldimines using a preformed NHC-copper(i) complex as the catalyst
Hensel, Alexander,Nagura, Kazuhiko,Delvos, Lukas B.,Oestreich, Martin
, p. 4964 - 4967 (2014)
A remaining major challenge in the asymmetric addition of silicon nucleophiles to typical prochiral acceptors, the enantioselective 1,2-addition to aldimines, is addressed. Activation of the Si-B bond in the silicon pronucleophile by a copper(I) alkoxide with McQuade's chiral six-membered N-heterocyclic carbene as a supporting ligand releases the silicon nucleophile, which adds to various aldimines with high levels of enantioselectivity. The new method provides a catalytic asymmetric access to α-silylated amines.
