1611495-08-9Relevant academic research and scientific papers
Asymmetric organocatalytic direct C(sp2)-H/C(sp3)-H oxidative cross-coupling by chiral iodine reagents
Wu, Hua,He, Yu-Ping,Xu, Lue,Zhang, Dong-Yang,Gong, Liu-Zhu
supporting information, p. 3466 - 3469 (2014/04/03)
An asymmetric organocatalytic direct C-H/C-H oxidative coupling reaction of N1,N3-diphenylmalonamides has been well established by using chiral organoiodine compounds as catalysts, wherein four C-H bonds were stereoselectively functionalized to give structurally diverse spirooxindoles with high levels of enantioselectivity. More importantly, the findings indicated that chiral hypervalent organoiodine reagents can serve as alternative catalysts for the creation of enantioselective functionalization of inactive C-H bonds. 'I' on the ball: The title oxidative coupling reaction of N 1,N3-diphenylmalonamides has been established by using chiral organoiodine compounds as catalysts. Four C-H bonds were stereoselectively functionalized to give spirooxindoles with high levels of enantioselectivity.
