161194-79-2

Upstream product

• 42469-26-1 N-(2-hydroxyethyl)-4-methylbenzamide 
• 870-24-6 2-chloroethanamine hydrochloride 
• 874-60-2 4-methyl-benzoyl chloride 
• 497-25-6 dimethylenecyclourethane 

Downstream Products

• 61320-58-9 2-(4-methylphenyl)-1-phenyl-4,5-dihydro-1H-imidazole 
• 10200-70-1 2-(4-methylphenyl)-4,5-dihydro-1,3-oxazole 

Relevant academic research and scientific papers

One-pot triflic anhydride-mediated synthesis of 1,2-disubstituted 2-imidazolines from N-(2-haloethyl)amides and amines

A one-pot synthesis of 1,2-disubstituted 2-imidazolines from N-(2-haloethyl)amides has been developed. The reaction affords high yields of diverse 1,2-disubstituted 2-imidazolines from triflic anhydride-mediated dehydration of amides followed by installat

NOVEL METHODS FOR THE TREATMENT OF INFLAMMATORY DISEASES

Methods of inhibiting the cytokine or biological activity of Macrophage Migration Inhibitory Factor (MIF) comprising contacting MIF with a compound of formula (I) are provided. The invention also relates to methods of treating diseases or conditions where MIF cytokine or biological activity is implicated comprising administration of compounds of formula (I), either alone or as a part of combination therapy. Novel compounds of formula (I) are also provided for.

The Use of 2-Oxazolidinone as a Latent Aziridine Equivalent. I. A Facile Method for the Preparation of 2-Substituted Oxazolines

Ring-opening reaction of 2-oxazolidinone with acid chlorides followed by treatment with aqueous sodium hydroxide yields 2-substituted oxazolines.