161196-41-4Relevant academic research and scientific papers
(2-hydroxy)ethyl-thioureas useful as modulators of alpha2B adrenergic receptors
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, (2008/06/13)
Compounds of formula (i) and of formula (ii) wherein the symbols have the meaning disclosed in the specification, specifically or selectively modulate α2B and/or α2C adrenergic receptors in preference over α2A adrenergic receptors, and as such are useful for alleviating chronic pain and allodynia and have no or only minimal cardivascular and/or sedatory activity.
Convergent Routes to the Dioxolophenanthridin-6(5H)-one and 2,3,4,4a-Tetrahydrodioxolophenanthridin-6(5H)-one Nuclei. Application to Syntheses of the Amaryllidaceae Alkaloids Crinasiadine, N-Methylcrinasiadine and Trisphaeridine
Banwell, Martin G.,Cowden, Cameron J.
, p. 2235 - 2254 (2007/10/02)
Convergent routes to the title nuclei, (1) and (6), have been developed.Thus, Suzuki coupling of boronic acid (8) with aryl bromide (9) gave the biarylylcarbamate (7) which, on treatment with phosphorus oxychloride (POCl3), underwent Bischler-Napieralski
