1612-98-2

Usage

General Description

1,3-Cyclohexanediol, 1-methyl-4-(1-methylethyl)- is a chemical compound combining 1,3-cyclohexanediol and 1-methyl-4-(1-methylethyl) groups. It is a colorless, odorless liquid with a molecular formula C9H20O2. This chemical is commonly used in the production of various industrial and consumer products, including plastics, solvents, and personal care products. It is also known for its use as a raw material in the synthesis of pharmaceuticals and agrochemicals. Additionally, it is utilized in biochemical research as a reagent and synthetic intermediate. While 1,3-Cyclohexanediol, 1-methyl-4-(1-methylethyl)- has several practical applications, it is important to handle it with care as it may pose health hazards if not properly managed.

Upstream product

• 6756-92-9 1-hydroxy-p-menthan-2-one 
• 23283-97-8 (+)-(1S,2R,5R)-isomenthol 
• 15356-60-2 (1S,2R,5S)-(+)-menthol 
• 193286-29-2 (3R)-3-hydroxy citronellal 
• 76936-25-9 (-)-(R)-3,7-Dimethyloct-6-en-1,3-diol 

Relevant academic research and scientific papers

Selective C-H bond hydroxylation of cyclohexanes in water by supramolecular control

A new approach for selective hydroxylation of non-activated cyclohexanes using dioxirane generated in situ in water through supramolecular control has been developed. Using β-CD and γ-CD as the supramolecular hosts, selective hydroxylation of cyclohexane substrates, including trans/cis-1,4-, 1,3-and 1,2-dimethylcyclohexanes and trans/cis-decahydronaphthalene, was achieved in up to 54% yield in water. Furthermore, site-selective C-H bond hydroxylation of (+)-menthol was achieved by obstructing the approach of dioxirane to the C-H bond with higher steric hindrance through inclusion complexation with β-CD and γ-CD in water.

Hydroxylation of (+)-menthol by Macrophomina phaseolina

Biotransformation of (+)-menthol with Macrophomina phaseolina led to hydroxylations at C-1, C-2, C-6, C-7, C-8 and C-9, with the C-8 position being preferentially oxidized. The resulting metabolites were identified as 8-hydroxymenthol (2), 6R-hydroxymenthol (3), 1R-hydroxymenthol (4), 9-hydroxymenthol (5), 2R,8-dihydroxymenthol (6), 8S,9-dihydroxymenthol (7), 6R,8-dihydroxymenthol (8), 1R,8-dihydroxymenthol (9) and 7,8-dihydroxymenthol (10). Metabolites 6-10 are described here for the first time. Their structures were characterized by spectroscopic analysis.

Enantioselective preparation of 1-hydroxy neoisopulegol and 1-hydroxy neoisomenthol

A enantioselective procedure is described for the preparation of (1R,3R,4R)-1-hydroxy isopulegol 3 and (1R,3S,4R)-1-hydroxy neoisopulegol 4 in 4 steps starting from geraniol. Their enantiomers (1S,3S,4S)-1-hydroxy isopulegol 5 and (1R,3S,4R)-1-hydroxy neo

PREPARATION OF BIOLOGICALLY ACTIVE SUBSTANCES AND ANIMAL AND MICROBIAL METABOLITES FROM MENTHOLS, CINEOLES AND KAURANES

Six monoterpenoids, l-menthol, l-menthyl acetate, iso-menthol, neo-menthol, 1,4-cineole and 1,8-cineole and one diterpene hydrocarbon, ent-kaurene were oxidized by meta-chloroperbenzoic acid or dry ozone to give various hydroxylated products and their structures elucidated by NMR spectroscopy.Some hydroxylated menthols showed plant growth inhibitory and strong mosquito repellent activity.Among the hydroxylated cineoles, microbial and animal metabolites of cineoles were included.From ent-kauranes, a plant growth inhibitory diterpene alcohol, (-)-16α-hydroxy kaurane was obtained along with 16α-kauran-13α-ol.