16120-53-9Relevant academic research and scientific papers
Asymmetric synthesis of spiro-epoxyoxindoles by the catalytic darzens reaction of isatins with phenacyl bromides
Kuang, Yulong,Lu, Yan,Tang, Yu,Liu, Xiaohua,Lin, Lili,Feng, Xiaoming
, p. 4244 - 4247 (2014)
The asymmetric Darzens reaction between phenacyl bromides and N-protected isatins was developed to synthesize potentially bioactive spiro-epoxyoxindoles. The optically active products were obtained in moderate to good yields and enantioselectivities catalyzed by chiral N,N′-dioxide-Co(acac)2 complexes. A retro-aldol process accompanying the ring-closure step was observed in the process. A chiral control step was determined to be the initial aldol addition.
