1612148-77-2

Upstream product

• 2243-56-3 1-naphthylhydrazine hydrochloride 

Downstream Products

• 1612148-57-8 (2S)-cyclohexyl({[5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoic acid 
• 1612149-04-8 tert-butyl (2S)-cyclohexyl({[5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)ethanoate 
• 1612148-59-0 1-({[5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]-carbonyl}amino)cyclohexanecarboxylic acid 
• 1612148-92-1 methyl 1-({[5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazol-3-yl]carbonyl}amino)cyclohexane carboxylate 
• 1612148-84-1 5-(2-methoxyphenyl)-1-naphthalen-1-yl-1H-pyrazole-3-carboxylic acid 

Relevant academic research and scientific papers

PYRAZOLE COMPOUNDS SELECTIVE FOR NEUROTENSIN 2 RECEPTOR

This invention relates generally to the discovery of pyrazole compounds selective for the neurotensin receptor 2 (NTR2) and uses thereof.

Identification of 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3- yl]carbonyl}amino)cyclohexane carboxylic acid as a selective nonpeptide neurotensin receptor type 2 compound

Compounds active at neurotensin receptors (NTS1 and NTS2) exert analgesic effects on different types of nociceptive modalities, including thermal, mechanical, and chemical stimuli. The NTS2 preferring peptide JMV-431 (2) and the NTS2 selective nonpeptide compound levocabastine (6) have been shown to be effective in relieving the pain associated with peripheral neuropathies. With the aim of identifying novel nonpeptide compounds selective for NTS2, we examined analogues of SR48692 (5a) using a FLIPR calcium assay in CHO cells stably expressing rat NTS2. This led to the discovery of the NTS2 selective nonpeptide compound 1-({[1-(4-fluorophenyl)-5-(2-methoxyphenyl)-1H-pyrazol-3-yl] carbonyl}amino)cyclohexane carboxylic acid (NTRC-739, 7b) starting from the nonselective compound 5a.