1612152-98-3Relevant academic research and scientific papers
Diastereoselective synthesis of n -aryl tetrahydroquinolines and n -aryl indolines by the tandem reaction of arynes
Pian, Ji-Xin,He, Lin,Du, Guang-Fen,Guo, Hao,Dai, Bin
, p. 5820 - 5826 (2014)
A tandem reaction of arynes with α- or β-amino ketones has been revealed. Arynes react with β-amino ketones through a cascade insertion-cyclization process to afford N-aryl tetrahydroquinolines in good yield with excellent anti-selectivity. Meanwhile, the coupling of arynes with α-amino ketones produces multisubstituted indolines in high yield with syn-selectivity. A quaternary carbon center can be constructed in this process, and the reaction can be easily scaled up.
