1612262-29-9Relevant academic research and scientific papers
Photocatalytic initiation of thiol-ene reactions: Synthesis of thiomorpholin-3-ones
Keylor, Mitchell H.,Park, James E.,Wallentin, Carl-Johan,Stephenson, Corey R.J.
, p. 4264 - 4269 (2014)
A mild, redox neutral photocatalytic method for alkene hydrothiolation is reported. Utilizing visible-light activation, catalytic radical initiation is achieved with the transition metal complex Ru(bpy)3Cl2, enabling rapid access to a diverse set of thiol-ene coupled products in excellent yield. On the basis of a strong observed background reaction in some cases, we have developed a solvent-free, Lewis acid-promoted tandem amidation-hydrothiolation sequence, providing thiomorpholin-3-ones in a one-pot operation from commercially available materials.
