1612263-37-2Relevant academic research and scientific papers
Pd/NHC-catalyzed enantiospecific and regioselective suzuki-miyaura arylation of 2-arylaziridines: Synthesis of enantioenriched 2-arylphenethylamine derivatives
Takeda, Youhei,Ikeda, Yuki,Kuroda, Akinobu,Tanaka, Shino,Minakata, Satoshi
, p. 8544 - 8547 (2014)
A palladium-catalyzed stereospecific and regioselective cross-coupling of enantiopure 2-arylaziridines with arylboronic acids under mild conditions to construct a tertiary stereogenic center has been developed. N-heterocyclic carbene (NHC) ligands efficiently promote the coupling, suppressing β-hydride elimination. The enantiospecific cross-coupling allowed us for preparation of a series of biologically important 2-arylphenethylamine derivatives in an enantiopure form.
