161252-79-5Relevant academic research and scientific papers
Tandem asymmetric syntheses from achiral precursors. Asymmetric homogeneous reduction of bisdehydrodipeptides
Baba, Sana El,Sartor, Karina,Poulin, Jean-Claude,Kagan, Henri B.
, p. 525 - 533 (2007/10/02)
Sequential asymmetric syntheses on an achiral substrate with two prochiral centers is a direct route to products with two asymmetric centers.The product distribution is discussed as a function of the various stereoselectivities.After a general presentation of double asymmetric syntheses, the specific case of asymmetric hydrogenation of some achiral bisdehydrodipeptides is considered.When the chiral ligand of the rhodium catalyst was dipamp, very high diastereoselectivities and enanatioselectivities with respect to resulting dipeptides could be achieved. bisdehydrodipeptides / dipeptides / diop / dipamp / bppm / two sequential asymmetric syntheses / stereoselective hydrogenation / enantioselectivity / diastereoselectivity
