161264-15-9

Upstream product

• 161264-11-5 (2R)-N-<(2S)-6--2-<amino>hexanoyl>bornane-10,2-sultam 
• 161264-05-7 (2R)-N-<<>(2S)-2-<amino>-6-iodohexan-1-oyl>bornane-10,2-sultam 
• 227185-30-0 N-acetyl-DL-2-amino-6-bromohexanoic acid 
• 622-33-3 N-benzyloxyamine 
• 727426-22-4 2-acetylamino-6-(acetyl-benzyloxy-amino)-hexanoic acid tert-butyl ester 
• 727426-13-3 2-acetylamino-6-bromo-hexanoic acid tert-butyl ester 
• 727426-07-5 2-acetylamino-6-benzyloxyamino-hexanoic acid tert-butyl ester 

Downstream Products

• 727426-48-4 (S)-6-(Acetyl-benzyloxy-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-hexanoic acid 2-trimethylsilanyl-ethyl ester 
• 727426-55-3 (S)-6-(Acetyl-benzyloxy-amino)-2-[(1-{(2S,3S)-2-[(R)-2-tert-butoxycarbonylamino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-hexanoic acid 
• 727426-62-2 (S)-6-(Acetyl-benzyloxy-amino)-2-[(1-{(2S,3S)-2-[(R)-2-amino-3-(4-methoxy-phenyl)-propionylamino]-3-methyl-pentanoyl}-piperidine-2-carbonyl)-amino]-hexanoic acid 
• 727426-32-6 6-(acetyl-benzyloxy-amino)-2-tert-butoxycarbonylamino-hexanoic acid 2-trimethylsilanyl-ethyl ester 
• 727426-44-0 (S)-6-(Acetyl-benzyloxy-amino)-2-amino-hexanoic acid 2-trimethylsilanyl-ethyl ester 
• 55024-36-7 (S)-N^ε-(benzyloxy)lysine 

Relevant academic research and scientific papers

Synthesis and histone deacetylase inhibitory activity of cyclic tetrapeptides containing a retrohydroxamate as zinc ligand

Cyclic tetrapeptide retrohydroxamic acids were prepared as histone deacetylase (HDAC) inhibitors and evaluated the inhibitory activity and found that they have potential as anticancer drugs.

Asymmetric alkylations of a sultam-derived glycine equivalent: Practical preparation of enantiomerically pure α-amino acids

Alkylation of the chiral glycine derivative 2 with 'activated' organohalides under ultrasound-assisted phase-transfer catalysis or with activated and nonactivatcd organohalides in anhydrous medium provides (mostly crystalline) alkylation products 3. Acidic hydrolysis of the pure products 3 gives (aminoacyl)sultams 4 which by mild saponification furnish pure α-amino acids 5 in good overall yields from 2, along with recovered auxiliary 1 (Scheme 1). Pure ω-protected α,ω-diamino acids and α-amino-ω-(hydroxyamino)acids 12-16 are readily accessible from (ω-haloacyl)sultams 3 via reaction with N-nucleophiles followed by acidic and basic hydrolyses (Scheme 2). A reliable determination of the enantiomeric purity of α-amino acids using HPLC analysis of their N-(3,5-dinitrobenzoyl)prolyl derivatives 17 is presented.