161264-46-6

Basic information

• Product Name: 1H-Pyrrolo[2,3-b]pyridin-1-amine(9CI)
• Synonyms: 1H-Pyrrolo[2,3-b]pyridin-1-amine(9CI)
• CAS NO: 161264-46-6
• Molecular Formula: C₇H₇N₃
• Molecular Weight: 133.15
• Product Categories: PYRIDINE
• Mol File: 161264-46-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 317.4±34.0 °C(Predicted)
• Appearance: /
• Density: 1.32±0.1 g/cm3(Predicted)
• PKA: 5.87±0.30(Predicted)
• CAS DataBase Reference: 1H-Pyrrolo[2,3-b]pyridin-1-amine(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 1H-Pyrrolo[2,3-b]pyridin-1-amine(9CI)(161264-46-6)
• EPA Substance Registry System: 1H-Pyrrolo[2,3-b]pyridin-1-amine(9CI)(161264-46-6)

Safety Data

• Hazardous Substances Data: 161264-46-6(Hazardous Substances Data)

Usage

Uses

1H-Pyrrolo[2,3-b]pyridin-1-amine is an intermediate in the preparation of PGDS inhibitors which are used for the treatment of allergic and inflammatory diseases.

Upstream product

• 271-63-6 7-Azaindole 

Downstream Products

• 348640-57-3 1-amino-1H-pyrrolo[2,3-b]pyridinium 2,4,6-trimethylphenylsulfonate 
• 271-63-6 7-Azaindole 

Relevant articles and documents

Synthesis of 1,4-dihydro-4-oxypyridazino[1,6-a]indole-3-carboxylic acids and 1,4-dihydro-4-oxopyrido[3',2':4,5]pyrrolo[1,2-b]-pyridazine-3-carboxyl ic acids as potential antibacterial agents

A few aza analogues of the quinolones have been prepared in the two milies of the 1,4-dihydro-4-oxopyridazino[1,6-a]indole-3-carboxylic acids and the 1,4-dihydro-4-oxopyrido[3',2':4,5]pyrrolo[1,2-b]pyridazine-3-carboxyli c acids to check their antibacterial potential. One compound 6c shows antibacterial activities of the level of nalidixic acid and represents a new lead structure differing from the classical quinolones.

N-Amination of Pyrrole and Indole Heterocycles with Monochloramine (N H2Cl)

A survey of several electrophilic ammonia reagents for the N-amination of indole- and pyrrole-containing heterocycles revealed that monochloramine (NH2Cl) is an excellent reagent for this transformation. Pyrroles and indoles containing a variety of substitution were aminated on nitrogen with isolated yields ranging from 45% to 97%.