161275-67-8

Upstream product

• 128916-31-4 (R)-(+)-2-[(4-methylphenyl)sulfinylmethyl]pyridine 
• 109-06-8 α-picoline 
• 59203-01-9 (S)-(+)-1-methyl 4-methylbenzenesulfinate 

Downstream Products

• 161275-66-7 (1S,S_S)-(-)-1-(2-pyridyl)-1-(4-methylphenylsulfinyl)ethane 
• 161151-97-9 (1R,S_S)-(+)-1-(2-pyridyl)-1-(4-methylphenylsulfinyl)propane 
• 161151-94-6 (1S,S_S)-(-)-1-(2-pyridyl)-1-(4-methylphenylsulfinyl)propane 
• 161151-92-4 (R)-tert-butyldimethylsiloxy(2-pyridyl)methyl 4-methylpheny sulfide 

Relevant academic research and scientific papers

Enzymatic kinetic resolution of chiral sulfoxides-an enantiocomplementary approach

A new enzymatic assay for the preparation of chiral sulfoxides that is enantiocomplementary to the known (S)-enantiomer-reducing activity of methionine sulfoxide reductase A (MsrA) is described. To this end, we have utilized the enzyme DMSO reductase (DmsABC), recently discovered by us being highly upregulated in stationary phase E. coli bacteria.

Enantioselective Pummerer-type rearrangement by reaction of O-silylated ketene acetal with enantiopure α-substituted sulfoxides

Chiral non-racemic α-substituted sulfoxides have been allowed to react with O-silylated ketene acetals in the presence of a catalytic amount of ZnI2 in THF to give chiral non-racemic α-siloxy sulfides in >99% ee. This is the highest enantioselectivity reported to date for the Pummerer reaction.