1612760-73-2Relevant academic research and scientific papers
New photocleavable linker: α-Thioacetophenone-type linker
Yonezawa, Hirotaka,Nishiyama, Yoshitake,Takeo, Koji,Iwatsubo, Takeshi,Tomita, Taisuke,Yokoshima, Satoshi,Fukuyama, Tohru
, p. 2831 - 2833 (2014/06/10)
Photocleavable linkers are advantageous over the common linkers because they could be cleaved without using reagents. A novel photocleavable linker with an α-thioacetophenone moiety has been developed. This linker, which can be cleaved upon irradiation at 365 nm via the Norrish type II reaction, is applicable to a protein affinity purification system, allowing target proteins to be effectively isolated. This novel linker would serve as an effective tool in chemical biology.
