161277-47-0

Basic information

• Product Name: Cyclohexanol, 2-(1-piperidinyl)-, (1R,2R)-
• CAS NO: 161277-47-0
• Molecular Formula: C11H21NO
• Molecular Weight: 183.294
• Mol File: 161277-47-0.mol

Chemical Properties

• CAS DataBase Reference: Cyclohexanol, 2-(1-piperidinyl)-, (1R,2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexanol, 2-(1-piperidinyl)-, (1R,2R)-(161277-47-0)
• EPA Substance Registry System: Cyclohexanol, 2-(1-piperidinyl)-, (1R,2R)-(161277-47-0)

Safety Data

• Hazardous Substances Data: 161277-47-0(Hazardous Substances Data)

Upstream product

• 110-89-4 piperidine 
• 286-20-4 cyclohexane-1,2-epoxide 
• 286-20-4 cyclohexene oxide 
• 111-24-0 1,5-dibromo-pentane 
• 931-15-7 (1R,2R)-2-aminocyclohexanol 

Relevant articles and documents

Chiral Co(III)-salen complex supported over highly ordered functionalized mesoporous silica for enantioselective aminolysis of racemic epoxides

Here we demonstrate the synthesis of a novel chiral Co(iii)-salen complex supported functionalized 2D-hexagonal mesoporous silica material Co(iii)@AFS-1. This material has shown excellent catalytic activity for the regio- and enantioselective asymmetric ring opening (ARO) of terminal and meso epoxides using various aromatic as well as cyclic amines to produce chiral β-amino alcohols having very good enantioselectivities (ee > 99%) at ambient temperature under solvent-free neat conditions.

A new recyclable functionalized mesoporous SBA-15 catalyst grafted with chiral Fe(iii) sites for the enantioselective aminolysis of racemic epoxides under solvent free conditions

An efficient and enantioselective strategy for the catalytic ring opening of racemic meso and terminal epoxides with aromatic as well as cyclic amine derivatives has been reported over a new mesoporous SBA-15 catalyst grafted with a chiral Fe(iii) complex

Resolution of racemic 2-aminocyclohexanol derivatives and their application as ligands in asymmetric catalysis

A preparatively easy and efficient protocol for the resolution of racemic 2-aminocyclohexanol derivatives is described, delivering both enantiomers with >99% enantiomeric excess (ee) by sequential use of (R)- and (S)-mandelic acid. A simple aqueous workup procedure permits the isolation of the amino alcohols in analytically pure form and the almost quantitative recovery of mandelic acid. Debenzylation of enantiopure trans-2-(N-benzyl)amino-1- cyclohexanol by hydrogenation and subsequent derivatization give access to a broad variety of diversely substituted derivatives. Furthermore, the corresponding cis isomers are readily available. Applications of these optically active aminocyclohexanols in catalyzed asymmetric phenyl transfer reactions to benzaldehydes and transfer hydrogenations of aryl ketones lead to products with up to 96% ee.