1612776-75-6Relevant academic research and scientific papers
Expansion of antibacterial spectrum of muraymycins toward pseudomonas aeruginosa
Takeoka, Yusuke,Tanino, Tetsuya,Sekiguchi, Mitsuaki,Yonezawa, Shuji,Sakagami, Masahiro,Takahashi, Fumiyo,Togame, Hiroko,Tanaka, Yoshikazu,Takemoto, Hiroshi,Ichikawa, Satoshi,Matsuda, Akira
, p. 556 - 560 (2014)
It is urgent to develop novel anti-Pseudomonas agents that should also be active against multidrug resistant P. aeruginosa. Expanding the antibacterial spectrum of muraymycins toward P. aeruginosa was investigated by the systematic structure-activity relationship study. It was revealed that two functional groups, a lipophilic side chain and a guanidino group, at the accessory moiety of muraymycins were important for the anti-Pseudomonas activity, and analogue 29 exhibited antibacterial activity against a range of P. aeruginosa strains with the minimum inhibitory concentration values of 4-8 μg/mL.
