1612824-64-2Relevant academic research and scientific papers
Regio- and enantioselective synthesis of N-allylindoles by iridium-catalyzed allylic amination/transition-metal-catalyzed cyclization reactions
Ye, Ke-Yin,Dai, Li-Xin,You, Shu-Li
supporting information, p. 3040 - 3044 (2014/03/21)
Regio- and enantioselective synthesis of N-allylindoles was realized through an iridium-catalyzed asymmetric allylic amination reaction with 2-alkynylanilines and subsequent transition-metal-catalyzed cyclization reactions. The highly enantioenriched allylic amines prepared from Ir-catalysis were treated with catalytic amount of NaAuCl4×2 H2O or PdCl2 providing various substituted N-allylindoles in excellent yields and enantioselectivities. Regio- and enantioselective synthesis of N-allylindoles was realized through an iridium-catalyzed asymmetric allylic amination reaction with 2-alkynylanilines and subsequent transition-metal- catalyzed cyclization reactions (see scheme). The highly enantioenriched allylic amines prepared from Ir catalysis were treated with catalytic amount of NaAuCl4×2 H2O or PdCl2 providing various substituted N-allylindoles in excellent yields and enantioselectivities (dbcot=dibenzo[a,e]cyclooctatetraene).
