1612872-83-9Relevant academic research and scientific papers
Iridium(III)-catalyzed direct C-7 amination of indolines with organic azides
Shin, Kwangmin,Chang, Sukbok
, p. 12197 - 12204 (2014)
Iridium-catalyzed regioselective C-7 amination of indolines has been achieved with organic azides as a facile nitrogen source. The developed procedure is convenient to perform even at room temperature and applicable to a wide range of substrates with high catalytic activity. Various types of organic azides (sulfonyl, aryl, and alkyl derivatives) were all successfully reacted under the present conditions as the viable reactant. Furthermore, indoline substrates bearing easily removable N-protecting groups such as N-Boc or N-Cbz could readily be employed, highlighting the synthetic utility of this methodology. (Chemical equation presented).
Ruthenium-catalyzed C7 amidation of indoline C-H bonds with sulfonyl azides
Pan, Changduo,Abdukader, Ablimit,Han, Jie,Cheng, Yixiang,Zhu, Chengjian
, p. 3606 - 3609 (2014/04/03)
A ruthenium-catalyzed direct C7 amidation of indoline C-H bonds with sulfonyl azides was developed. This procedure allows the synthesis of a variety of 7-amino-substituted indolines, which are useful in pharmaceutical. The good functional tolerances, as well as the mild conditions, are prominent feature of this method.
