1612875-56-5Relevant academic research and scientific papers
Surface-Improved Asymmetric Michael Addition Catalyzed by Amino Acids Adsorbed on Laponite
Sz?ll?si, Gy?rgy,Gombk?t?, Dániel,Mogyorós, Attila Zsolt,Fül?p, Ferenc
, p. 1992 - 2004 (2018)
An unprecedented enantioselectivity increase was observed in the presence of inorganic oxides in the asymmetric Michael addition of aldehydes to trans-β-nitrostyrene derivatives catalyzed by amino acids. The best results were reached in the l-proline cata
Synthesis ofN-alkylated lipopeptides and their application as organocatalysts in asymmetric Michael addition in aqueous environments
Corrêa, Arlene G.,Delgado, José A. C.,Fernandes, Vitor A.,Paix?o, Márcio W.,Vicente, Fidel E. M.,de la Torre, Alexander F.
supporting information, p. 14050 - 14057 (2021/08/16)
A library ofN-alkylated lipopeptide organocatalysts were synthesized through an isocyanide-based multicomponent reaction. Various structural motifs were tunably introduced on the catalyst backbone with the aim of incorporating amphiphilic features. Conseq
Polyethylene glycol (PEG) as a reusable solvent medium for an asymmetric organocatalytic Michael addition. Application to the synthesis of bioactive compounds
Feu, Karla S.,De La Torre, Alexander F.,Silva, Sandrina,De Moraes Junior, Marco A.F.,Correa, Arlene G.,Paixao, Marcio W.
supporting information, p. 3169 - 3174 (2014/06/10)
A highly stereoselective organocatalytic Michael addition of aldehydes to trans-β-nitrostyrenes using PEG as a recyclable solvent medium is presented. The scope of this organocatalytic system is demonstrated by the formation of several Michael adducts in good yields and stereoselectivities. Furthermore, applying this new protocol to acetaldehyde, we have disclosed an easy formal synthesis of (R)-pregabalin, (R)-phenibut and (R)-bacoflen with good yields and outstanding enantioselectivities. This journal is the Partner Organisations 2014.
