1612881-86-3

Basic information

• Product Name: (3-(4-methoxybenzyl)-2-oxooxazolidin-5-yl)methyl 4-methylbenzenesulfonate
• Synonyms: (3-(4-methoxybenzyl)-2-oxooxazolidin-5-yl)methyl 4-methylbenzenesulfonate
• CAS NO: 1612881-86-3
• Molecular Weight: 391.445
• Mol File: 1612881-86-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (3-(4-methoxybenzyl)-2-oxooxazolidin-5-yl)methyl 4-methylbenzenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: (3-(4-methoxybenzyl)-2-oxooxazolidin-5-yl)methyl 4-methylbenzenesulfonate(1612881-86-3)
• EPA Substance Registry System: (3-(4-methoxybenzyl)-2-oxooxazolidin-5-yl)methyl 4-methylbenzenesulfonate(1612881-86-3)

Safety Data

• Hazardous Substances Data: 1612881-86-3(Hazardous Substances Data)

Upstream product

• 2393-23-9 4-methoxy-benzylamine 
• 1612881-72-7 5-(hydroxymethyl)-3-[(4-methoxyphenyl)methyl]-1,3-oxazolidin-2-one 
• 103057-51-8 hypochlorous acid 4-methylbenzene sulfonic anhydride 

Downstream Products

• 1612878-90-6 5-((4-benzhydrylpiperazin-1-yl)methyl)-3-(4-methoxybenzyl)oxazolidin-2-one 

Relevant articles and documents

Discovery of oxazolidinone-based heterocycles as subtype selective sigma-2 ligands

The sigma-2 (σ2) receptor, also known as the Transmembrane Protein 97 (TMEM97, and MAC30 (Meningioma-associated protein), has been linked to a number of conditions are disease states such as schizophrenia, cancer, Alzheimer’s disease, traumatic brain injury, and neuropathic pain. As part or our on-going effort identify novel σ2 ligands, we have identified a series of novel, functionalized oxazolidin-2-one sigma-2 ligands (4). Our lead compound (4h) demonstrated high affinity (Ki = 36 nM) and excellent σ1/σ2 selectivity (79-fold). Evaluation of its affinity at key CNS targets via the Psychoactive Drug Screening Program (PDSP) also indicated a high degree of selectivity for σ2 over other receptors. [Figure not available: see fulltext.].