1612886-77-7

Basic information

• Product Name: 4-phenyl-2-(pyridin-4-yl)thiazole-5-carbonitrile
• Synonyms: 4-phenyl-2-(pyridin-4-yl)thiazole-5-carbonitrile
• CAS NO: 1612886-77-7
• Molecular Weight: 263.323
• Mol File: 1612886-77-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-phenyl-2-(pyridin-4-yl)thiazole-5-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyl-2-(pyridin-4-yl)thiazole-5-carbonitrile(1612886-77-7)
• EPA Substance Registry System: 4-phenyl-2-(pyridin-4-yl)thiazole-5-carbonitrile(1612886-77-7)

Safety Data

• Hazardous Substances Data: 1612886-77-7(Hazardous Substances Data)

Upstream product

• 1612886-73-3 4-phenyl-2-(pyridin-4-yl)thiazole-5-carboxamide 

Downstream Products

• 1612886-78-8 4-phenyl-2-(pyridin-4-yl)-5-(2H-tetrazol-5-yl)thiazole 

Relevant articles and documents

Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors

The Cell division cycle 7 (Cdc7) protein kinase is essential for DNA replication and maintenance of genome stability. We systematically explored thiazole-based compounds as inhibitors of Cdc7 kinase activity in cancer cells. Our studies resulted in the identification of a potent, selective Cdc7 inhibitor that decreased phosphorylation of the direct substrate MCM2 in vitro and in vivo, and inhibited DNA synthesis and cell viability in vitro.