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1612886-77-7

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1612886-77-7 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1612886-77-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,1,2,8,8 and 6 respectively; the second part has 2 digits, 7 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1612886-77:
(9*1)+(8*6)+(7*1)+(6*2)+(5*8)+(4*8)+(3*6)+(2*7)+(1*7)=187
187 % 10 = 7
So 1612886-77-7 is a valid CAS Registry Number.

1612886-77-7Relevant articles and documents

Synthesis and structure-activity relationship of trisubstituted thiazoles as Cdc7 kinase inhibitors

Reichelt, Andreas,Bailis, Julie M.,Bartberger, Michael D.,Yao, Guomin,Shu, Hong,Kaller, Matthew R.,Allen, John G.,Weidner, Margaret F.,Keegan, Kathleen S.,Dao, Jennifer H.

, p. 364 - 382 (2014)

The Cell division cycle 7 (Cdc7) protein kinase is essential for DNA replication and maintenance of genome stability. We systematically explored thiazole-based compounds as inhibitors of Cdc7 kinase activity in cancer cells. Our studies resulted in the identification of a potent, selective Cdc7 inhibitor that decreased phosphorylation of the direct substrate MCM2 in vitro and in vivo, and inhibited DNA synthesis and cell viability in vitro.

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