161292-70-2Relevant academic research and scientific papers
TRICYCLIC QUINOXALINEDIONE DERIVATIVES
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, (2008/06/13)
A tricyclic quinoxalinedione derivative represented by the formula 1: STR1 wherein X represents hydrogen, alkyl, halogen, cyano, trifluoromethyl, or nitro;R 1 represents hydrogen, alkyl, cycloalkyl, or cycloalkylalkyl;G represents--CONR 2--or--NR 2 CO--, wherein R 2 represents hydrogen or alkyl;J represents an acidic group or a group which is convertible thereto in vivo;E represents an basic group or a group which is convertible thereto in vivo;Y represents a single bond, alkylene, alkenylene, substituted alkylene, or Y 1--Q--Y 2, wherein Y 1 represents a single bond or alkylene, Y 2 represents alkylene, and Q represents a heteroatom selected from oxygen or sulfur;Z represents alkylene, or a pharmaceutically acceptable salt thereof, these compounds are selective antagonists of glycine binding site of the NMDA receptor.
