1613027-08-9Relevant academic research and scientific papers
A rhodium-catalyzed cascade cyclization: Direct synthesis of N-substituted phthalimides from isocyanates and benzoic acids
Shi, Xian-Ying,Renzetti, Andrea,Kundu, Soumen,Li, Chao-Jun
supporting information, p. 723 - 728 (2014/04/03)
A rhodium(III)-catalyzed amidation between benzoic acids and isocyanates via direct functionalization of an ortho C-H bond followed by intramolecular cyclization is described. This cascade cyclization affords N-substituted phthalimides in one step in 26-91% yields. The reaction is highly atom-economical, since no theoretical waste except for water is generated in the reaction.
