1613035-87-2

Upstream product

• 1613035-86-1 (S)-2-((((3-bromo-7-hydroxy-2-oxo-2H-pyrano[2,3-b]pyridin-4-yl)methoxy)carbonyl)amino)-pentanedioic acid 
• 1613035-85-0 (S)-4-amino-5-((3-bromo-7-hydroxy-2-oxo-2H-pyrano[2,3-b]pyridin-4-yl)methoxy)-5-oxopentanoic acid 

Relevant academic research and scientific papers

Development of the 8-aza-3-bromo-7-hydroxycoumarin-4-ylmethyl group as a new entry of photolabile protecting groups

A significant substitution effect of the position of the bromo group on the photosensitivity of the 8-azacoumarin chromophore leads to the development of a highly photosensitive 8-aza-3-bromo-7-hydroxycoumarin-4-ylmethyl (aza-3-Bhc) group that shows excellent photolytic efficiency and hydrophilicity with long-wavelength absorption maxima. The newly identified aza-3-Bhc group can be applied to caged glutamates for ester-type and carbamate-type protections of carboxyl and amino functionalities.