1613041-52-3Relevant academic research and scientific papers
Domino synthesis of 1,3-diynes from 1,1-dibromoalkenes: A Pd-catalyzed copper-free coupling method
Rao, Maddali L.N.,Dasgupta, Priyabrata,Ramakrishna, Boddu S.,Murty, Venneti N.
, p. 3529 - 3533 (2014)
Pd-catalyzed domino synthesis of 1,3-diynes was accomplished using 1,1-dibomoalkenes under copper-free coupling conditions. This domino procedure involves base mediated in situ generation of 1-bromoalkyne and its subsequent coupling to give 1,3-diyne. The optimized copper-free coupling method afforded good to high yields of symmetrical 1,3-diynes in a one-pot operation.
