1613063-61-8

Basic information

• Product Name: 2-cyano-N-(furan-2-ylmethyl)-N-(4-hydroxyphenyl)acetamide
• Synonyms: 2-cyano-N-(furan-2-ylmethyl)-N-(4-hydroxyphenyl)acetamide
• CAS NO: 1613063-61-8
• Molecular Weight: 256.261
• Mol File: 1613063-61-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-cyano-N-(furan-2-ylmethyl)-N-(4-hydroxyphenyl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-cyano-N-(furan-2-ylmethyl)-N-(4-hydroxyphenyl)acetamide(1613063-61-8)
• EPA Substance Registry System: 2-cyano-N-(furan-2-ylmethyl)-N-(4-hydroxyphenyl)acetamide(1613063-61-8)

Safety Data

• Hazardous Substances Data: 1613063-61-8(Hazardous Substances Data)

Upstream product

• 98-01-1 furfural 
• 123-30-8 4-amino-phenol 
• 123558-04-3 2-furfuryl-p-hydroxyphenyleneamine 
• 372-09-8 cyanoacetic acid 

Relevant articles and documents

Versatile synthesis of 4-spiro-β-lactam-3-carbonitriles via the intramolecular nucleophilic cyclization of N-(p-hydroxyphenyl)cyanoacetamides

A series of 4-spiro-cyclohexadienonyl-β-lactam-3-carbonitriles, 2,7-dioxo-1-azaspiro[3.5]nona-5,8-diene-3-carbonitriles, was synthesized in satisfactory to excellent yields via the intramolecular nucleophilic cyclization of N-(p-hydroxyphenyl)cyanoacetamides with iodobenzene diacetate (IBD) as oxidant and potassium hydroxide as base. Acetic 4-spiro-cyclohexadienonyl- β-lactam-3-carbimidic anhydrides were obtained when organic base triethylamine was applied instead of potassium hydroxide. The mechanisms of the intramolecular nucleophilic cyclization and formation of acetic β-lactam-3-carbimidic anhydrides were proposed. The cyclization is a sequence of nucleophilic ipso addition and oxidative dearomatization. The formation of acetic carbimidic anhydrides is an acid-catalyzed acetate addition to the nitriles.