1613082-54-4

Basic information

• Product Name: 1-(4-nitrobenzyl)-3-(4-(2-morpholinoethyl)piperazin-1-yl)quinoxalin-2(1H)-one
• Synonyms: 1-(4-nitrobenzyl)-3-(4-(2-morpholinoethyl)piperazin-1-yl)quinoxalin-2(1H)-one
• CAS NO: 1613082-54-4
• Molecular Weight: 478.551
• Mol File: 1613082-54-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(4-nitrobenzyl)-3-(4-(2-morpholinoethyl)piperazin-1-yl)quinoxalin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-nitrobenzyl)-3-(4-(2-morpholinoethyl)piperazin-1-yl)quinoxalin-2(1H)-one(1613082-54-4)
• EPA Substance Registry System: 1-(4-nitrobenzyl)-3-(4-(2-morpholinoethyl)piperazin-1-yl)quinoxalin-2(1H)-one(1613082-54-4)

Safety Data

• Hazardous Substances Data: 1613082-54-4(Hazardous Substances Data)

Upstream product

• 100-11-8 1-bromomethyl-4-nitro-benzene 
• 35676-70-1 3-chloro-quinoxaline-2(1H)-one 
• 1613082-51-1 C₁₅H₁₀ClN₃O₃ 
• 4892-89-1 4-(2-(piperazin-1-yl)ethyl)morpholine 

Relevant articles and documents

Structure-activity relationships studies of quinoxalinone derivatives as aldose reductase inhibitors

Novel quinoxalinone derivatives were synthesized and tested for their inhibitory activity against aldose reductase. Among them, N1-acetate derivatives had significant activity in a range of IC50 values from low micromolar to submicromolar, and compound 15a bearing a C3-phenethyl side chain was identified as the most potent inhibitor with an IC50 value of 0.143 μM. The structure-activity studies suggested that both C3-phenethyl and C6-NO2 groups play an important role in enhancing the activity and selectivity of the quinoxalinone based inhibitors.