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1613135-54-8

[3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]methyl 4-methylbenzenesulfonate is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 1613135-54-8 Structure

  • Basic information

    1. Product Name: [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]methyl 4-methylbenzenesulfonate
    2. Synonyms: [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]methyl 4-methylbenzenesulfonate
    3. CAS NO:1613135-54-8
    4. Molecular Formula:
    5. Molecular Weight: 429.881
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 1613135-54-8.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]methyl 4-methylbenzenesulfonate(CAS DataBase Reference)
    10. NIST Chemistry Reference: [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]methyl 4-methylbenzenesulfonate(1613135-54-8)
    11. EPA Substance Registry System: [3-(5-chlorofuran-2-yl)-4-phenylisoxazol-5-yl]methyl 4-methylbenzenesulfonate(1613135-54-8)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 1613135-54-8(Hazardous Substances Data)

1613135-54-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 1613135-54-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,6,1,3,1,3 and 5 respectively; the second part has 2 digits, 5 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1613135-54:
(9*1)+(8*6)+(7*1)+(6*3)+(5*1)+(4*3)+(3*5)+(2*5)+(1*4)=128
128 % 10 = 8
So 1613135-54-8 is a valid CAS Registry Number.

1613135-54-8Relevant articles and documents

PET radiotracer [18F]-P6 selectively targeting COX-1 as a novel biomarker in ovarian cancer: Preliminary investigation

Perrone, Maria Grazia,Malerba, Paola,Uddin, Md. Jashim,Vitale, Paola,Panella, Andrea,Crews, Brenda C.,Daniel, Cristina K.,Ghebreselasie, Kebreab,Nickels, Mike,Tantawy, Mohammed N.,Manning, H. Charles,Marnett, Lawrence J.,Scilimati, Antonio

, p. 562 - 568 (2014)

Cyclooxygenase-1 (COX-1), but not COX-2, is expressed at high levels in the early stages of human epithelial ovarian cancer where it seems to play a key role in cancer onset and progression. As a consequence, COX-1 is an ideal biomarker for early ovarian cancer detection. A series of novel fluorinated COX-1-targeted imaging agents derived from P6 was developed by using a highly selective COX-1 inhibitor as a lead compound. Among these new compounds, designed by structural modification of P6, 3-(5-chlorofuran-2-yl)-5- (fluoromethyl)-4-phenylisoxazole ([18/19F]-P6) is the most promising derivative [IC50 = 2.0 μM (purified oCOX-1) and 1.37 μM (hOVCAR-3 cell COX-1)]. Its tosylate precursor was also prepared and, a method for radio[18F]chemistry was developed and optimized. The radiochemistry was carried out using a carrier-free K18F/Kryptofix 2.2.2 complex, that afforded [18F]-P6 in good radiochemical yield (18%) and high purity (>95%). In vivo PET/CT imaging data showed that the radiotracer [18F]-P6 was selectively taken up by COX-1-expressing ovarian carcinoma (OVCAR 3) tumor xenografts as compared with the normal leg muscle. Our results suggest that [18F]-P6 might be an useful radiotracer in preclinical and clinical settings for in vivo PET-CT imaging of tissues that express elevated levels of COX-1.

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