1613142-48-5

Basic information

• Product Name: (E)-4-[3-(3-(4-methoxy-2-nitrophenyl)ureido)phenyl]-1-[1′-deoxy-β-D-glucopyranos-1′-yl]but-3-en-2-one
• Synonyms: (E)-4-[3-(3-(4-methoxy-2-nitrophenyl)ureido)phenyl]-1-[1′-deoxy-β-D-glucopyranos-1′-yl]but-3-en-2-one
• CAS NO: 1613142-48-5
• Molecular Weight: 517.492
• Mol File: 1613142-48-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (E)-4-[3-(3-(4-methoxy-2-nitrophenyl)ureido)phenyl]-1-[1′-deoxy-β-D-glucopyranos-1′-yl]but-3-en-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-[3-(3-(4-methoxy-2-nitrophenyl)ureido)phenyl]-1-[1′-deoxy-β-D-glucopyranos-1′-yl]but-3-en-2-one(1613142-48-5)
• EPA Substance Registry System: (E)-4-[3-(3-(4-methoxy-2-nitrophenyl)ureido)phenyl]-1-[1′-deoxy-β-D-glucopyranos-1′-yl]but-3-en-2-one(1613142-48-5)

Safety Data

• Hazardous Substances Data: 1613142-48-5(Hazardous Substances Data)

Upstream product

• 1042966-19-7 (E)-4-(3-nitrophenyl)-1-[1'-deoxy-2',3',4',6'-tetra-O-acetyl-β-D-glucopyranos-1'-yl]but-3-en-2-one 
• 99-61-6 3-nitro-benzaldehyde 
• 1426398-75-5 (E)-4-(3-aminophenyl)-1-[1'-deoxy-2',3',4',6'-tetra-O-acetyl-β-D-glucopyranos-1'-yl]but-3-en-2-one 
• 117162-85-3 1-isocyanato-4-methoxy-2-nitrobenzene 
• 1613142-37-2 (E)-4-[3-(3-(4-methoxy-2-nitrophenyl)ureido)phenyl]-1-[1′-deoxy-2′,3′,4′,6′-tetra-O-acetyl-β-D-glucopyranos-1′-yl]but-3-en-2-one 

Relevant articles and documents

Identification of novel phenyl butenonyl C-glycosides with ureidyl and sulfonamidyl moieties as antimalarial agents

A new series of C-linked phenyl butenonyl glycosides bearing ureidyl(thioureidyl) and sulfonamidyl moieties in the phenyl rings were designed, synthesized, and evaluated for their in vitro antimalarial activities against Plasmodium falciparum 3D7 (CQ sensitive) and K1 (CQ resistant) strains. Among all the compounds screened the C-linked phenyl butenonyl glycosides bearing sulfonamidyl moiety (5a) and ureidyl moiety in the phenyl ring (7d and 8c) showed promising antimalarial activities against both 3D7 and K1 strains with IC50 values in micromolar range and low cytotoxicity offering new HITS for further exploration.