1613148-88-1

Basic information

• Product Name: N-(4-methoxy-2-nitrophenyl)pyridin-2-amine
• Synonyms: N-(4-methoxy-2-nitrophenyl)pyridin-2-amine
• CAS NO: 1613148-88-1
• Molecular Weight: 245.238
• Mol File: 1613148-88-1.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-methoxy-2-nitrophenyl)pyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-methoxy-2-nitrophenyl)pyridin-2-amine(1613148-88-1)
• EPA Substance Registry System: N-(4-methoxy-2-nitrophenyl)pyridin-2-amine(1613148-88-1)

Safety Data

• Hazardous Substances Data: 1613148-88-1(Hazardous Substances Data)

Upstream product

• 78644-78-7 N-(4-methoxyphenyl)pyridin-2-amine 
• 504-29-0 2-aminopyridine 
• 5344-78-5 4-bromo-3-nitroanizole 

Relevant articles and documents

Cobalt-Catalyzed Regioselective Ortho C(sp2)-H Bond Nitration of Aromatics through Proton-Coupled Electron Transfer Assistance

A cobalt-catalyzed proton-coupled electron transfer (PCET) mediated regioselective ortho-specific nitration of aromatic C(sp2)-H bonds using chelation-assisted removable vicinal diamine directing groups was developed. The reaction proceeded under mild conditions in the presence of Co(OAc)2·4H2O as the catalyst with AgNO2 utilized as the nitro source as well as terminal oxidant in the presence of O2 as an external oxidant. No external base or additives were required for this process. Controlled experiments and mechanistic investigations with DFT calculations revealed that the reaction proceeds through a PCET promoted nitro functional group transfer pathway. Moreover, the produced compounds are valuable and pharmaceutically quite relevant.