1613159-60-6Relevant academic research and scientific papers
Silver-catalyzed synthesis of 3-phosphorated coumarins via radical cyclization of alkynoates and dialkyl H -phosphonates
Mi, Xia,Wang, Chenyang,Huang, Mengmeng,Zhang, Jianye,Wu, Yusheng,Wu, Yangjie
supporting information, p. 3356 - 3359 (2014/07/08)
Ag2CO3-catalyzed difunctionalization of alkynes via a radical phosphonation and C-H functionalization tandem process was developed to synthesize various 3-phosphonated coumarins in moderate to high yields with high regioselectivity. A catalytic amount of cheap and nontoxic silver salt was employed in the domino C-P and C-C formation of alkynoates for the first time. Mechanistic studies indicate that the reaction pathway might proceed via the generation and cyclization of a phosphonated vinyl radical intermediate.
